By Dave Isay
In ALL THERE, StoryCorps founder Dave Isay stocks tales of affection and marriage from the progressive oral historical past undertaking, revealing the various and noteworthy trips that relationships can take.
In tales that hold us from the buzz and anticipation of courtship to the deep connection of lifelong dedication, we find that love is located within the such a lot unforeseen of places—a ny tollbooth, an army base in Iraq, an airport lounge—and research that the path it takes is as unpredictable as existence itself. because the storytellers during this e-book commence careers, construct houses, and lift households, we witness the life-affirming pleasure of partnership, the relaxation of shared sorrows, and profound gratitude within the face of loss.
those tales also are testomony to the heart’s notable patience. In ALL there's we stumble upon love that survives discrimination, ailment, poverty, distance—even demise. within the braveness of people’s ardour we're reminded of the energy and resilience of the human spirit. This robust assortment bares witness to true love, in its many different types, enriching our knowing of that almost all magical feeling.
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This scene clearly makes another point that I have been advancing in debate-like dialogue with still another real-life colleague—in this case a charmingly friendly but still quite earnest opponent of my views. That point is that dreaming, psychedelic drug taking, and organic delirium all share a common chemical mechanism: an alteration of neuromodulatory balance. So this dream scene, like the others, is a self-fulfilling hypothesis: dreaming is an artful illusion, akin to psychosis, a delightful madhouse whose form is universal and whose content, while particular in some respects, is greatly constrained—and shaped—by the universal forms.
Psychedelics alter consciousness in psychopathological directions, but because they are (mostly) reversible, they constitute round-trip tickets to and from forbidden zones in brain-mind space. There are good trips and bad trips. Good trips are characterized by altered perceptions and enhanced mood; bad trips by altered perceptions, fear, anxiety, and depressed—or violent—mood. LSD, the psychedelic drug par excellence, can cause both good and bad trips, depending on the individual taking it, the expectations and context of the taker, and the dose and purity of the LSD.
How States of Consciousness Alter 43 with dopamine, norepinephrine, and serotonin, but all of these systems interact synergistically to create the chemical background conditions of thought, feeling, and action. In depression, the beneficial effects of enhancing the synaptic efficacy of norepinephrine and especially serotonin (while simultaneously countering acetylcholine’s efficacy) runs hand in hand with their suppressive effects on REM sleep and dreaming. This observation entails a powerful consilience of our models of mood control and dream control and is one of the most impressive scientific revelations of contemporary psychiatry.