Advances in Mutagenesis Research by V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter

By V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)

Utilized genetic learn, genetic toxicology and mutation examine examine the mutagenicity and cancerogenicity of chemical compounds and different brokers. everlasting mutation in genes and chromosomes, should be brought on through aplethora of brokers, together with ionizing and nonionizing radiations, chemical compounds, and viruses. one of the features discused via Advances in Mutagenesis learn are (1) the certainty of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate creation of mutagenic brokers into the surroundings. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his lifestyles and medical Achievements. - Arylnitrenium Ions and the Genotoxic efficiency of fragrant Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical constitution in numerous sequence of comparable Compounds. - Formation of 8-Hydroxyguanine by way of Oxidative DNA harm, its fix and its Mutagenic results. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of brought on Mutagenesis via Ultraviolet mild in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the identity of SCEs in keeping with telephone Cycle: basics and functions. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi research. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.

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31 32 34 40 42 43 1 Introduction In 1982 the analysis of DNA ad ducts was carried out, particularly guanine ad ducts, as one approach to the identification of direct-acting mutagens present in broiled foods and environmental materials. On analysis of adduct formation by heated glucose, as a model of broiled foods, glyoxal-Gua and 8-hydroxy-Gua (oh BGua)l adducts were detected as major products (Kasai, et al. 1984a; Fig. 1). Hydroxylation of Gua at the C-8 position was a new type of guanine modification at that time.

2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 44000 ± 2420 39200 ± 2930 13400 ± 670 4320 ± 312 3470 ± 165 2630 ± 92 1100 ± 96 61 936 ± 695 ± 22 613 ± 50 40 330 ± 122 ± 14 3,3 38,1 ± 20,3 ± 1,8 16,1 ± 0,5 15,0 ± 1,8 3,3 ± 0,4 2,7 ± 0,1 2,4 ± 0,2 1,6 ± 0,1 1,3 ± 0,1 0,6 ± 0,1 0,05 0,2 ± <0,04 <0,04 <0,04 0,5 1,2 0,5 0,5 0,oI 1,6 0,7 0,17 1,0 0,4 0,1 1,0 2,4 1,0 0,4 0,1 0,3 0,15 0,25 0,7 1,5 1,1 1,3 Azido-isoIQ Azido-MeIQ Azido-IQ Azido-isoNI l-Azidopyrene Azido-MeIQx Azido-NI 6-Azidochrysene 2-Azidofluorene Azido-PhlP 4,4'-Diazidodiphenyl 4-Azidofluorene 2-Azido-l-methylbenzimidazole 4-Azidodiphenyl 2-Azidonaphthalene 6-Azidoquinoline 4,4'-Diazidodiphenylmethane 5-Azidoquinoline l-Azidonaphthalene 2-Azidobenzimidazole 2,4,6-Trichlorophenylazide 2,4,6-Trimethylphenylazide 2,4,5-Trimethylphenylazide 2-Azidodiphenyl 2,6-Dimethylphenylazide Phenylazide (Azidobenzene) t50: NUV-irradiation time required for half-maximal mutation induction; the values of the mutagenic potencies were obtained with severalfold longer irradiations and are therefore maximal values for a given azide.

Moriya et al. (1991) prepared plasmid DNA with a six-nucleotide gap opposite ohBGua and transfected it into E. coli. After replication of the plasmid, the sequence of DNA corresponding to the gap was determined by the oligonucleotide hybridization method. In this analysis both nonmutagenic and mutagenic events could be detected. 6%. In the two experiments above, DNA which contains ohBGua in the single-stranded region was transfected into E. coli. Since ohBGua in single-stranded DNA is not repaired by an E.

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