By John G. Bartlett MD
Designed to supply easy access to criteria of deal with infectious ailment through concentrating on choice, right doses, bills, and negative effects of antimicrobial brokers, the 2005-2006 notebook of Infectious sickness Therapy attracts widely from suggestions made via the facilities for disorder keep an eye on and Prevention, the clinical Letter on medicinal drugs and Therapeutics, and from respectable statements of revered clinical societies. Tabular fabric has been up to date to incorporate all newly licensed antibiotics, in addition to new strategies for management.
This variation comprises topical matters corresponding to MRSA (USA three hundred strain), Avian influenza, Acinetobacter Hepatitis B virus (HBV), hepatitis C virus (HCV), and bioterrorism. It additionally includes the recent guidance for pyogenic meningitis, diabetic foot infections, healthcare linked pneumonia, surgical prophylaxis, fungal infections, bacteruria, and administration of infections linked to overseas travel.
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Additional info for 2005-2006 Pocket Book of Infectious Disease Therapy
3. Adjustments in dose are usually based on creatinine clearance that may be estimated by the Cockcroft-Gault equation (Nephron 16:31, 1976). 85 Pitfalls and notations with calculations follow. a. Elderly patient: Serum creatinine may be deceptively low (with danger of overdosing) because of reduced muscle mass. b. Pregnancy, ascites, and other causes of volume expansion: GFR may be increased (with danger of underdosing) in third trimester of pregnancy and patients with normal renal function who receive massive parenteral fluids.
Pneumoniae—see below) Cephalosporin (1st gen), cefuroxime, cefotaxime, ceftriaxone; Erythromycin, clarithromycin, azithromycin Vancomycin; clindamycin; tigecycline Endocarditis Penicillin G ± streptomycin or gentamicin Cephalosporin: Parenteral—see above vancomycin Beta-lactams S. saprophyticus S. epidermidis S. iniae S. pneumoniae (see p 253) Bacteremia, cellulitis Penicillin, clindamycin Meningitis (see p 233) Ocular infections Vancomycin + cefotaxime or ceftriaxone Cefotaxime; ceftriaxone (activity variable) S.
5 g q24 h Ceftriaxone Renal and biliary 69 1215 — 1-2 g q24h Usu al Usual Usu al Cefuroxime Renal 1. 31. 7 5g q24 h Cefuroxime axetil Renal 1. 2 20 250 mg q12 h — Usu al Usual 250 mg q24 h Cephalexin Renal 0. 2 5-1 g q24 48h Cephalothin Renal 0. 50. 5 g q8h Cephapirin Renal 0. 60. 52g q12 h Cephradine Renal 0. 51g q24 72h Chlorampheni col Hepatic 2. 25 -1 g q6h Usu al Usual Usu al Chloroquine Renal and metaboliz ed 48 12 0 ? 300 600 mg po qd — Usu al Usual 150 300 mg po qd Cidofovir Renal 17 65 ↑ — 5 mg/ kg q 2 wk Usu al Contraindica ted Cinoxacin Renal 1.